ESA PROJECTS

Czech  Orbital   NanoRobots   Experiment 

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Mission Overview

CONREX – Czech Orbital NanoRobots EXperiment is a pioneering biotechnological experiment designed to test nano and micro robots for the eradication of bacterial biofilms under microgravity conditions aboard the International Space Station (ISS).
Biofilms — microbial layers highly resistant to antibiotics — pose major risks to astronaut health, spacecraft systems, and long-duration missions. CONREX evaluates how autonomous microrobots can mechanically disrupt and degrade biofilms, offering a revolutionary new approach to infection control in space and on Earth.

Conrex Facts

Nanorobots in Space

the First experiment globally

Experiment Launch

2028 Expected

Development Time

24 months

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Technology and Experiment Concept

The experiment uses magnetically controlled and photosensitive microrobots placed inside sealed microcells filled with biofilms.
An electromagnetic coil system generates precisely oriented 3D magnetic fields to steer the microrobots, while a digital microscope records their movement and biofilm removal in real time.
The hardware operates within the ICE Cubes Facility on the ISS, with astronauts exchanging up to 20 microcells during the campaign. Data and videos are stored onboard and downlinked for scientific analysis.

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Scientific Objectives

Assess the efficacy of magnetic microrobots in removing bacterial biofilms in microgravity.

Study the motion dynamics and propulsion of light-driven and magnetic nanorobots under space conditions.

Investigate how microgravity affects biofilm resistance and microrobot performance.

Compare space and ground control data to optimize future microrobot designs for biomedical and industrial applications.

 

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Earth and Space Benefits

In space, CONREX supports crew health and spacecraft safety by addressing biofilm buildup in life-support systems — a critical risk for Lunar Gateway and Mars missions.
On Earth, the same technology could transform infection control, medical device hygiene, and industrial biofouling prevention, providing a non-antibiotic alternative to fighting resistant bacteria.
The findings will advance both space health systems and biomedical nanotechnology for terrestrial use.

 

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Mission Consortium

The CONREX project is led by VSB – Technical University of Ostrava, with TRL Space (Czech Republic) responsible for space engineering, integration, and safety assurance, and supported by the ICE Cubes Facility (Belgium) for ISS operations.
The experiment follows ESA and ECSS standards for safety, qualification, and ISS compatibility.

Questions and Downloads

Why microgravity?

Biofilms behave differently in space; performance must be validated in orbit.

Is it flight hardware already?

Hardware is being prepared within the national ISS experiment programme; some Czech experiments may fly earlier than the astronaut’s mission depending on readiness.

Who leads the science?

VŠB‑TUO research teams in collaboration with TRL Space.

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